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The peptide simply does not interact with the receptors and pathways that stimulate IGF-1 production

This lipid radical reacts with molecular oxygen to form a lipid peroxyl radical (LOO), which can propagate the chain reaction by abstracting hydrogen atoms from neighboring lipids, leading to the generation of more lipid radicals and peroxyl radicals [9]

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Eriksson et al., 2008)

This extended half-life is also why results take time to appear